The expression of recombinant proteins
can lead to selective negative growing
pressure. Cells expressing recombinant ion channel membrane proteins are espe-
cially prone to loosing their expression
ability after few passages even under selection pressure.
The IGAMI technology enables the fast generation of ion channel CHO-K1 cell lines with long term expression stability.
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The IGAMI technology was successfully used in development of several ion channel cell lines like
- Potassium Channels
- Calcium Channels
- Transient Receptor Potential Channels
- Ligand Gated Channels
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